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In a small, prematurely terminated study of patients with pulmonary hypertension (PH) secondary to sickle cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo.
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Finally, if sildenafil is administered orally with food, the rate of absorption is observed to be decreased with a mean delay in Tmax of about 60 minutes and a mean decrease in Cmax of approximately 29% .
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Risk Summary Limited published veri from a case report describe the presence of sildenafil and its active metabolite in human milk. Daha fazla bilgi There is insufficient information about the effects of sildenafil on the breastfed infant and no information on the effects of sildenafil on milk production.
Should signs of daha fazla bilgi al pulmonary edema occur when sildenafil is administered, consider the possibility of associated PVOD.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.
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